اثر هیپوگلیسمیک و هیپولیپیدمیک مصرف خوراکی سیر وحشی در موش صحرایی دیابتی

Introduction: The hypoglycemic and hypolipidemic effects of Allium ursinum(AU) were investigated in an experimental model of diabetes mellitus, invitro. Methods: Male Wistar rats were divided into control, AU-treated control, diabetic glibenclamide-treated, and AU-treated diabetic groups. For induction of diabetes, streptozocin(STZ) was intraperitoneally administered(60 mg/Kg). AU-treated groups received AU mixed with standard pelleted food at a weight ratio of 1% for 2 months. Serum glucose and lipids levels were determined before the study and at the 4th and 8th week after the study. Results: Serum glucose was significantly lower in AU-treated diabetic rats at the end of the 4th and 8th weeks(p<0.005 and p<0.01 respectively) as compared to untreated diabetics. Serum total cholesterol, triglyceride, and HDL-cholesterol levels did not show a significant change in AU-treated diabetic rats as compared to untreated diabetics. On the other hand, LDL-cholesterol levels decreased in AU-treated diabetic group as compared to untreated diabetic group(p<0.05). Conclusion: Oral administration of AU has a significant hypoglycemic effect and in long term leads to decreased levels of serum LDL-cholesterol in diabetic rats.